Sirtuin inhibitor sirtinol is an intracellular iron chelator.
نویسندگان
چکیده
Sirtinol is a known inhibitor of sirtuin proteins, a family of deacetylases involved in the pathophysiology of aging. Spectroscopic and structural data reveal that this compound is also an iron chelator forming high-spin ferric species in vitro and in cultured leukemia cells. Interactions with the highly regulated iron pool therefore contribute to its overall intracellular agenda.
منابع مشابه
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ورودعنوان ژورنال:
- Chemical communications
دوره 51 24 شماره
صفحات -
تاریخ انتشار 2015